HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA PDF

The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.

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Views Read Edit View history. Please add a reason or a talk parameter to this template to explain the issue with the article. The human telomere sequence itself is a tandem repeat: Studies have shown [ citation needed ] that the evolutionary fate of minisatellites tends towards an equilibrium distribution in the size of alleles, until mutations in the flanking DNA affect the recombinational activity of a minisatellite by suppressing DNA instability.

Minisatellites were subsequently also used for genetic markers in linkage analysis minizatellite population studies, but were soon replaced by microsatellite profiling in the s. Such an event would ultimately lead to the extinction of a hypermutable minisatellite by meiotic drive.

Sign in via your Institution Sign in. In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements.

Hypervariable ‘minisatellite’ regions in human DNA.

Since all hypermutable minisatellites contain internal variantsthey provide extremely informative systems for analyzing the complex turnover processes that occur ih this class of tandem repeat. Receive exclusive offers and updates monisatellite Oxford Academic. Wikipedia articles needing clarification from July All Wikipedia articles needing clarification Articles needing expert attention with no reason or talk parameter Articles needing expert attention from July All articles needing expert attention Genetics articles needing expert attention Articles with multiple maintenance issues All articles with unsourced statements Articles with unsourced statements from May Dynamic evolution of megasatellites in yeasts.

Please help improve it or discuss these issues on the talk page. These findings have suggested that minisatellites most probably evolved as bystanders of localized meiotic recombination hotspots in the human genome.

WikiProject Genetics may be able to help recruit an expert. You must accept the terms and conditions. Finally, miniastellite the discovery of tandem iterations of simple sequence motifs, the term microsatellites was coined.

Learn how and when to remove these template messages. Minisatellite variant repeat mapping by PCR MVR-PCR has been extensively used to chart the interspersion patterns of variant repeats along the array, which provides details on the structure of the alleles before and after mutation. I agree to the terms and conditions. The first human minisatellite was discovered in by A. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide.

Hypervariable ‘minisatellite’ regions in human DNA.

Emery’s Elements of Medical Genetics, 12th. July Learn how and when to remove this template message. Sign In Forgot password? Minisatellites also constitute the chromosomal telomeres, which protect the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes. Minisatellites have been implicated [ citation needed ] as regulators of gene expression e. This article is also available for minisatllite through DeepDyve. In contrast, complex inter-allelic conversion-like events occur in the germline.

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Minisatellites are small sequences of DNA that do not encode proteins but appear throughout the genome hundreds of minisateloite, with many repeated copies lying next to each other.

We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function.

Related articles in Web of Science Google Scholar. By using this site, you agree to the Terms of Use and Privacy Policy. Thank you for submitting a comment on this article. Hypervariable minisatellites have core units 9—64 bp long and are found mainly at the centromeric regions. Your comment will be reviewed and published at the journal’s discretion.

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